| First Author | Ali K | Year | 2008 |
| Journal | J Immunol | Volume | 180 |
| Issue | 4 | Pages | 2538-44 |
| PubMed ID | 18250464 | Mgi Jnum | J:131982 |
| Mgi Id | MGI:3774901 | Doi | 10.4049/jimmunol.180.4.2538 |
| Citation | Ali K, et al. (2008) Isoform-specific functions of phosphoinositide 3-kinases: p110delta but not p110gamma promotes optimal allergic responses in vivo. J Immunol 180(4):2538-44 |
| abstractText | The leukocyte-enriched p110gamma and p110delta isoforms of PI3K have been shown to control in vitro degranulation of mast cells induced by cross-linking of the high affinity receptor of IgE (FcepsilonRI). However, the relative contribution of these PI3K isoforms in IgE-dependent allergic responses in vivo is controversial. A side-by-side comparative analysis of the role of p110gamma and p110delta in mast cell function, using genetic approaches and newly developed isoform-selective pharmacologic inhibitors, confirms that both PI3K isoforms play an important role in FcepsilonRI-activated mast cell degranulation in vitro. In vivo, however, only p110delta was found to be required for optimal IgE/Ag-dependent hypersensitivity responses in mice. These observations identify p110delta as a key therapeutic target among PI3K isoforms for allergy- and mast cell-related diseases. |
