| First Author | Alfonso C | Year | 2003 |
| Journal | Eur J Immunol | Volume | 33 |
| Issue | 7 | Pages | 2014-21 |
| PubMed ID | 12884868 | Mgi Jnum | J:131508 |
| Mgi Id | MGI:3773825 | Doi | 10.1002/eji.200323853 |
| Citation | Alfonso C, et al. (2003) H2-O influence on antigen presentation in H2-E-expressing mice. Eur J Immunol 33(7):2014-21 |
| abstractText | MHC class II molecules sample peptides generated in the endosomal/lysosomal system for cell surface presentation to CD4+ T cells. Peptide loading requires the endosomal/lysosomal resident HLA-DM (DM; H2-DM, mouse), but in B cells, DM is tightly associated with HLA-DO (DO; H2-O, mouse). We have previously shown that H2-O differentially modulates the processing and presentation of different antigenic epitopes on H2-Ab molecules. Using H2-Ead-transgenic mice, we here show that presentation of different epitopes by H2-Ed/b molecules is similarly influenced by H2-O after membrane immunoglobulin-mediated uptake of antigen. In addition, B cells from H2-Ead-transgenic mice (which co-express H2-Ab and H2-Ed/b molecules) show an altered pattern of presentation of H2-Ab-restricted epitopes. In H2-Ead-transgenic, H2-O-deficient mice, further changes in the peptide repertoire were observed. Thus, H2-Ed/b expression influences the epitopes presented by H2-Ab, and this effect is further altered by expression of H2-O. |
