First Author | Kuwabara Y | Year | 2020 |
Journal | Commun Biol | Volume | 3 |
Issue | 1 | Pages | 434 |
PubMed ID | 32792557 | Mgi Jnum | J:293789 |
Mgi Id | MGI:6453704 | Doi | 10.1038/s42003-020-01164-0 |
Citation | Kuwabara Y, et al. (2020) Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload. Commun Biol 3(1):434 |
abstractText | Recent high-throughput approaches have revealed a vast number of transcripts with unknown functions. Many of these transcripts are long noncoding RNAs (lncRNAs), and intergenic region-derived lncRNAs are classified as long intergenic noncoding RNAs (lincRNAs). Although Myosin heavy chain 6 (Myh6) encoding primary contractile protein is down-regulated in stressed hearts, the underlying mechanisms are not fully clarified especially in terms of lincRNAs. Here, we screen upregulated lincRNAs in pressure overloaded hearts and identify a muscle-abundant lincRNA termed Lionheart. Compared with controls, deletion of the Lionheart in mice leads to decreased systolic function and a reduction in MYH6 protein levels following pressure overload. We reveal decreased MYH6 results from an interaction between Lionheart and Purine-rich element-binding protein A after pressure overload. Furthermore, human LIONHEART levels in left ventricular biopsy specimens positively correlate with cardiac systolic function. Our results demonstrate Lionheart plays a pivotal role in cardiac remodeling via regulation of MYH6. |