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Allele : Mdm4<tm1.1Wahl> transformed mouse 3T3 cell double minute 4; targeted mutation 1.1, Goeff Wahl

Primary Identifier  MGI:3850668 Allele Type  Targeted
Gene  Mdm4 Transmission  Germline
Strain of Origin  129/Sv Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 11 was replaced with one in which codons for serines 341, 367, and 402 were modified to code for alanines. A floxed neo cassette upstream of the modified exon 11 was used for selection but was removed by cre expression in ES cells. These serines are located at conserved Chk2 sites and are necessary for protein degradation.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Mdmx<3SA>,
  • Mdmx<3SA>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories

Trail: Allele