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Allele : Del(4Cdkn2a-Cdkn2b)2Brn deletion, Chr 4, Anton Berns 2
Primary Identifier  MGI:3767464 Allele Type  Targeted
Attribute String  Null/knockout Gene  Del(4Cdkn2a-Cdkn2b)2Brn
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
description  ES cells used possessed the Cdkn2atm1.1Brn and Cdkn2btm2Brn alleles on the same chromosome.
molecularNote  Germ line cre mediated recombination between the loxP site in Cdkn2btm2Brn and the loxP site in Cdkn2atm1.1Brn deleted a genomic segment encompassing the promoter of Cdkn2b and intron 2 of the Cdkn2a exon 1a. The absence of p15Ink4b, p16Ink4a and p19Arf protein products was confirmed by western blot analysis on mouse embryonic fibroblasts.
  • mutations:
  • Intragenic deletion,
  • Intergenic deletion
  • synonyms:
  • Cdkn2a/Cdkn2b<tm2Brn>,
  • Cdkn2a/Cdkn2b<tm2Nki>,
  • Cdkn2a/Cdkn2b<tm2Brn>,
  • Cdkn2a/Cdkn2b<tm2Nki>,
  • Cdkn2ab<->,
  • Cdkn2ab<->,
  • Del2Brn,
  • Del2Brn
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2 Mutation Involves

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