| First Author | Hegel JK | Year | 2009 |
| Journal | Eur J Immunol | Volume | 39 |
| Issue | 3 | Pages | 883-93 |
| PubMed ID | 19224637 | Mgi Jnum | J:146787 |
| Mgi Id | MGI:3838445 | Doi | 10.1002/eji.200838770 |
| Citation | Hegel JK, et al. (2009) CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin. Eur J Immunol 39(3):883-93 |
| abstractText | CD8(+) T lymphocytes are required for effective host defense against pathogens and also for mediating effector responses against uncontrolled proliferating self-tissues. In this study, we determine that individual CD8(+) T cells are tightly controlled in their effector functions by CD152 (CTLA-4). We demonstrate that signals induced by CD152 reduce the frequency of IFN-gamma and granzyme B expressing CD8(+) T cells independently of the transcription factors T-bet or cKrox by selectively inhibiting accumulation of Eomesodermin mRNA and protein. Ectopic expression of Eomesodermin reversed the CD152-mediated inhibition of effector molecule production. Additionally, enhanced cytotoxicity of individual CD8(+) T cells differentiated in the absence of CD152 signaling was determined in vivo. These novel insights extend our understanding of how immune responses of CD8(+) T cells are selectively modulated. |
