Primary Identifier | MGI:2450735 | Allele Type | Targeted |
Gene | Rag2 | Transmission | Germline |
Strain of Origin | 129S6/SvEvTac | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The endogenous locus was replaced with a floxed neo cassette followed by cDNA sequence encoding a mutant truncated RAG2 protein ('core' RAG2) lacking the C-terminal 144 amino acids. The floxed neo cassette was subsequently removed by transient expression of cre recombinase in correctly targeted cells. |