| First Author | Wu C | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 5 | Pages | 410-4 |
| PubMed ID | 11323694 | Mgi Jnum | J:97756 |
| Mgi Id | MGI:3576261 | Doi | 10.1038/87713 |
| Citation | Wu C, et al. (2001) SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nat Immunol 2(5):410-4 |
| abstractText | SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency. SAP-deficient mice infected with lymphocytic choriomeningitis virus had greatly increased numbers of CD8+ and CD4+ interferon-gamma-producing spleen and liver cells compared to wild-type mice. The immune responses of SAP-deficient mice to infection with Leishmania major together with in vitro studies showed that activated SAP-deficient T cells had an impaired ability to differentiate into T helper 2 cells. The aberrant immune responses in SAP-deficient mice show that SAP controls several distinct key T cell signal transduction pathways, which explains in part the complexity of the XLP phenotypes. |
