| First Author | Wu J | Year | 2019 |
| Journal | FEBS Lett | Volume | 593 |
| Issue | 10 | Pages | 1020-1029 |
| PubMed ID | 31017652 | Mgi Jnum | J:289190 |
| Mgi Id | MGI:6434649 | Doi | 10.1002/1873-3468.13393 |
| Citation | Wu J, et al. (2019) Regulatory T cells sense effector T-cell activation through synchronized JunB expression. FEBS Lett 593(10):1020-1029 |
| abstractText | To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor JunB, which is induced in Teffs upon T-cell receptor (TCR) activation, is also increased in Tregs by TCR stimuli. Treg-specific deletion of Junb impairs Treg identity, causes uncontrolled inflammatory cytokine production by Teffs and leads to the T-box transcription factor T-bet-dependent spontaneous inflammation. Furthermore, JunB deficiency in Tregs unleashes antitumor Teff responses in a mouse model of melanoma. We conclude that JunB alarms Tregs of the emerging Teff activation and synchronizes immune regulation with the immune reaction in autoimmunity and cancer. |
