| First Author | Hulbert C | Year | 2001 |
| Journal | J Immunol | Volume | 167 |
| Issue | 10 | Pages | 5535-8 |
| PubMed ID | 11698422 | Mgi Jnum | J:91865 |
| Mgi Id | MGI:3051054 | Doi | 10.4049/jimmunol.167.10.5535 |
| Citation | Hulbert C, et al. (2001) B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol 167(10):5535-8 |
| abstractText | Type I diabetes mellitus (TIDM) is an autoimmune disorder characterized by T cell-mediated destruction of insulin-producing beta cells in the pancreas. In the nonobese diabetic (NOD) model of TIDM, insulitis and diabetes are dependent on the presence of B lymphocytes; however, the requirement for specificity within the B cell repertoire is not known. To determine the role of Ag-specific B cells in TIDM, V(H) genes with different potential for insulin binding were introduced into NOD as H chain transgenes. VH125 H chain combines with endogenous L chains to produce a repertoire in which 1-3% of mature B cells are insulin specific, and these mice develop accelerated diabetes. In contrast, NOD mice harboring a similar transgene, VH281, with limited insulin binding develop insulitis but are protected from TIDM. The data indicate that Ag-specific components in the B cell repertoire may alter the course of TIDM. |
