| First Author | Zhang T | Year | 2021 |
| Journal | Dev Dyn | Volume | 250 |
| Issue | 10 | Pages | 1450-1462 |
| PubMed ID | 33715274 | Mgi Jnum | J:311538 |
| Mgi Id | MGI:6771427 | Doi | 10.1002/dvdy.326 |
| Citation | Zhang T, et al. (2021) Eya2 expression during mouse embryonic development revealed by Eya2(lacZ) knockin reporter and homozygous mice show mild hearing loss. Dev Dyn 250(10):1450-1462 |
| abstractText | BACKGROUND: Eya2 expression during mouse development has been studied by in situ hybridization and it has been shown to be involved skeletal muscle development and limb formation. Here, we generated Eya2 knockout (Eya2(-) ) and a lacZ knockin reporter (Eya2(lacZ) ) mice and performed a detailed expression analysis for Eya2(lacZ) at different developmental stages to trace Eya2(lacZ) -positive cells in Eya2-null mice. We describe that Eya2 is not only expressed in cranial sensory and dorsal root ganglia, retina and olfactory epithelium, and somites as previously reported, but also Eya2 is specifically detected in other organs during mouse development. RESULTS: We found that Eya2 is expressed in ocular and trochlear motor neurons. In the inner ear, Eya2(lacZ) is specifically expressed in differentiating hair cells in both vestibular and cochlear sensory epithelia of the inner ear and Eya2(-/-) or Eya2(lacZ/lacZ) mice displayed mild hearing loss. Furthermore, we detected Eya2 expression during both salivary gland and thymus development and Eya2-null mice had a smaller thymus. CONCLUSIONS: As Eya2 is coexpressed with other members of the Eya family genes, these results together highlight that Eya2 as a potential regulator may act synergistically with other Eya genes to regulate the differentiation of the inner ear sensory hair cells and the formation of the salivary gland and thymus. |
