| First Author | Ozdoğan UK | Year | 2004 |
| Journal | Eur J Pharmacol | Volume | 485 |
| Issue | 1-3 | Pages | 193-6 |
| PubMed ID | 14757140 | Mgi Jnum | J:103497 |
| Mgi Id | MGI:3609588 | Doi | 10.1016/j.ejphar.2003.11.047 |
| Citation | Ozdogan UK, et al. (2004) Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice. Eur J Pharmacol 485(1-3):193-6 |
| abstractText | Tricyclic antidepressants have analgesic and sedative effects in addition to their antidepressive properties. We tested the acute analgesic and locomotor inhibitory effects of the tricyclic antidepressant amitriptyline and the alpha(2)-adrenoceptor agonist clonidine in wild-type control and in alpha(2A)-adrenoceptor knockout mice in hot-plate and tail-flick tests. Amitriptyline-induced analgesia was lost in alpha(2A)-adrenoceptor knockout mice. The locomotor inhibitory effect of amitriptyline was reduced, but not fully abolished in alpha(2A)-adrenoceptor knockout mice. Similar results were obtained with clonidine. We conclude that alpha(2A)-adrenoceptors appear to have a significant role in amitriptyline-induced acute analgesia in mice, and that alpha(2A)-adrenoceptors also participate in the sedative effects of amitriptyline. |
