| First Author | Park SJ | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 24 | Pages | 4303-10 |
| PubMed ID | 23123158 | Mgi Jnum | J:192272 |
| Mgi Id | MGI:5464242 | Doi | 10.1016/j.febslet.2012.10.035 |
| Citation | Park SJ, et al. (2012) Mitochondrial fragmentation caused by phenanthroline promotes mitophagy. FEBS Lett 586(24):4303-10 |
| abstractText | Mitochondrial dynamics and mitophagy are thought to be important events for the quality control of mitochondria and mitochondria-associated diseases. To identify novel mitophagy modulators, we developed a cell-based screening system and selected 1,10-phenanthroline (Phen) as a target molecule. Phen treatment highly induced mitochondrial fragmentation and mitochondrial dysfunctions in a Drp1 dependent manner. Phen treatment also increased autophagy. Moreover, prolonged exposure of Phen increased mitochondria clearance through mitophagy. Phen-mediated loss of mitochondrial mass was more reduced in ATG5 deficient cells than in wild type cells. In addition, down-regulation of Drp1 decreased autophagy activation, suggesting that mitochondrial fission is involved in Phen-mediated mitophagy. Thus, our results demonstrate that the disruption of mitochondrial dynamics and mitochondrial dysfunctions provokes mitophagy in Phen-treated cells. |
