Primary Identifier | MGI:5446719 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Pank2 |
Transmission | Germline | Strain of Origin | 129S/SvEv |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A floxed allele was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and exon 3. Total PanK enzyme activity was reduced 30% in the liver and 90% in the brain. |