Primary Identifier | MGI:3715537 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(282M13-Ank*G389R)1Kng |
Strain of Origin | FVB/N or (C57BL/6 x CBA)F1/J | Is Recombinase | false |
Is Wild Type | false |
description | Transgene was inserted into the nuclei of fertilized eggs from FVB/N or (C57BL/6 x CBA)F1/J mice. |
molecularNote | A point mutation was made in the Ank gene contained within Tg(282M13)1Kng converting a glycine to a arginine at amino acid position 389. This mutation is commonly found in craniometaphyseal dysplasia (CMD) patients and has little to no PPi-transport activity in vitro. |