| First Author | Wu YY | Year | 2015 |
| Journal | Mol Reprod Dev | Volume | 82 |
| Issue | 6 | Pages | 432-40 |
| PubMed ID | 25930072 | Mgi Jnum | J:301832 |
| Mgi Id | MGI:6507298 | Doi | 10.1002/mrd.22491 |
| Citation | Wu YY, et al. (2015) Targeted disruption of the spermatid-specific gene Spata31 causes male infertility. Mol Reprod Dev 82(6):432-40 |
| abstractText | Spata31, a novel testis-specific gene, was first isolated from the testis of a vitamin A-deficient rat model. To gain insight into its physiological function, Spata31-targeted knockout mice were generated by homologous recombination. Spata31-deficient (Spata31(flox/flox) ; Vasa-Cre) male mice exhibited low sperm count and premature shedding of germ cells into the lumen, ultimately causing azoospermia and male sterility. Mechanistically, the Spata31 deficiency resulted in reduced expression of the adhesion protein nectin-3 and cytoskeletal protein beta-actin at the apical ectoplasmic specialization. Our findings demonstrate that the disruptions to the SPATA31 ortholog could be linked to human male infertility. |
