| First Author | He W | Year | 2019 |
| Journal | Biochem Biophys Res Commun | Volume | 515 |
| Issue | 1 | Pages | 119-124 |
| PubMed ID | 31128921 | Mgi Jnum | J:291086 |
| Mgi Id | MGI:6442630 | Doi | 10.1016/j.bbrc.2019.04.185 |
| Citation | He W, et al. (2019) Dynamic expression of alpha6 integrin indicates epidermal cell behaviors. Biochem Biophys Res Commun 515(1):119-124 |
| abstractText | Skin epidermis is a stratified epithelium that composed of interfollicular epidermis (IFE) and hair follicles (HFs). Integrins are cell-cell and cell-matrix adhesive ligands that play important roles in epidermal cell proliferation, migration and differentiation behaviors. Here, we analyzed the expression of both alpha6 and beta1 integrins. In vitro epidermal cell culture, both alpha6 and beta1 integrins displayed downregulation upon high Ca(2+) induced differentiation. During wound healing (WH), alpha6 integrin showed dynamic expression, first greatly upregulated in unclosed wounds and then downregulated upon re-epithelialization. Further analysis of different wound regions confirmed alpha6 integrin significantly increased in migratory cells and migration was coupled with differentiation. However, expression level of beta1 integrin did not show significant correlation with migration. We discovered that alpha6 integrin directly indicates epidermal cell differentiation and wound directed migration behaviors with its expression level. |
