| First Author | Liu Y | Year | 2019 |
| Journal | Sci Adv | Volume | 5 |
| Issue | 4 | Pages | eaav7803 |
| PubMed ID | 31001589 | Mgi Jnum | J:287674 |
| Mgi Id | MGI:6415842 | Doi | 10.1126/sciadv.aav7803 |
| Citation | Liu Y, et al. (2019) Critical role of spectrin in hearing development and deafness. Sci Adv 5(4):eaav7803 |
| abstractText | Inner ear hair cells (HCs) detect sound through the deflection of mechanosensory stereocilia. Stereocilia are inserted into the cuticular plate of HCs by parallel actin rootlets, where they convert sound-induced mechanical vibrations into electrical signals. The molecules that support these rootlets and enable them to withstand constant mechanical stresses underpin our ability to hear. However, the structures of these molecules have remained unknown. We hypothesized that alphaII- and betaII-spectrin subunits fulfill this role, and investigated their structural organization in rodent HCs. Using super-resolution fluorescence imaging, we found that spectrin formed ring-like structures around the base of stereocilia rootlets. These spectrin rings were associated with the hearing ability of mice. Further, HC-specific, betaII-spectrin knockout mice displayed profound deafness. Overall, our work has identified and characterized structures of spectrin that play a crucial role in mammalian hearing development. |
