Primary Identifier | MGI:2445422 | Allele Type | Spontaneous |
Gene | Cdc25a | Strain of Origin | BALB/cJ |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A transversion mutation (C to A) resulted in a histidine to glutamine substitution at codon 128. The mutation is in a region of 24 conserved residues in the amino terminal non-catalytic domain and was demonstrated by biochemical assays to confer increased phosphatase activity. Identification of this allele was facilitated by linkage to Mst1rFv2. |