| First Author | Suber F | Year | 2007 |
| Journal | Proc Natl Acad Sci U S A | Volume | 104 |
| Issue | 10 | Pages | 3973-7 |
| PubMed ID | 17360462 | Mgi Jnum | J:120063 |
| Mgi Id | MGI:3703819 | Doi | 10.1073/pnas.0609026104 |
| Citation | Suber F, et al. (2007) Innate response to self-antigen significantly exacerbates burn wound depth. Proc Natl Acad Sci U S A 104(10):3973-7 |
| abstractText | A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response. |
