| First Author | Liu X | Year | 2012 |
| Journal | J Exp Med | Volume | 209 |
| Issue | 10 | Pages | 1841-52, S1-24 |
| PubMed ID | 22987803 | Mgi Jnum | J:191271 |
| Mgi Id | MGI:5461394 | Doi | 10.1084/jem.20120219 |
| Citation | Liu X, et al. (2012) Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med 209(10):1841-52, S1-24 |
| abstractText | T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage reporter systems. Assisted with genome-wide transcriptome analysis, we show substantial plasticity of T cell differentiation in the early phase of immune response. At this stage, CXCR5 appears to be expressed in a Bcl6-independent manner. Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program. |
