| First Author | Stittrich AB | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 11 | Pages | 1057-62 |
| PubMed ID | 20935646 | Mgi Jnum | J:166537 |
| Mgi Id | MGI:4847991 | Doi | 10.1038/ni.1945 |
| Citation | Stittrich AB, et al. (2010) The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol 11(11):1057-62 |
| abstractText | After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor-mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. Specific inhibition of miR-182 in helper T lymphocytes limited their population expansion in vitro and in vivo. Our results demonstrate a central role for miR-182 in the physiological regulation of IL-2-driven helper T cell-mediated immune responses and open new therapeutic possibilities. |
