| First Author | Zheng SJ | Year | 2005 |
| Journal | Diabetes | Volume | 54 |
| Issue | 5 | Pages | 1423-8 |
| PubMed ID | 15855329 | Mgi Jnum | J:105195 |
| Mgi Id | MGI:3614308 | Doi | 10.2337/diabetes.54.5.1423 |
| Citation | Zheng SJ, et al. (2005) Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 54(5):1423-8 |
| abstractText | The tumor suppressor p53 regulates apoptosis, cell cycle, and oncogenesis. To explore the roles of p53 in autoimmunity, we studied type 1 diabetes and innate immune responses using C57BL/6 mice deficient in p53. We found that p53-deficient mice were more susceptible to streptozotocin-induced diabetes than control mice, and they produced higher levels of interleukin-1, -6, and -12. The innate immune response of p53-/- macrophages to lipopolysaccharides and gamma-interferon was significantly enhanced compared with p53+/+ cells. p53-/- macrophages produced more proinflammatory cytokines and higher levels of total and phosphorylated signal transducer and activator of transcription (STAT)-1. These results indicate that p53 inhibits autoimmune diabetes and innate immune responses through downregulating STAT-1 and proinflammatory cytokines. |
