| First Author | Tyurin VA | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 413 |
| Issue | 1 | Pages | 149-53 |
| PubMed ID | 21872574 | Mgi Jnum | J:177532 |
| Mgi Id | MGI:5295349 | Doi | 10.1016/j.bbrc.2011.08.074 |
| Citation | Tyurin VA, et al. (2011) Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals. Biochem Biophys Res Commun 413(1):149-53 |
| abstractText | Dendritic cells are the most potent antigen presenting cells responsible for the development of immune responses in cancer. However, it is known that the function of dendritic cells in tumor-bearing hosts is severely compromised. Our previous studies demonstrated that the defects in dendritic cell function are due, to a large extent, to the accumulation of high amounts of lipids--predominantly triglycerides--in a substantial proportion of dendritic cells in tumor-bearing mice and patients with cancer. The dendritic cells accumulation of lipids is likely associated with their up-regulation of a scavenger receptor A. This receptor is primarily responsible for uptake of modified lipids. Here, by using different versions of liquid chromatography-mass spectrometry, we identified several molecular species of oxygenated lipids in plasma of tumor-bearing animals that may be responsible for their uptake and accumulation by dendritic cells via scavenger receptor A-dependent pathway--the effect that may be associated with the loss of dendritic cell's immune surveillance function in cancer. |
