| First Author | Keenan ID | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 13 | Pages | 1790-4 |
| PubMed ID | 22613570 | Mgi Jnum | J:185540 |
| Mgi Id | MGI:5429126 | Doi | 10.1016/j.febslet.2012.05.014 |
| Citation | Keenan ID, et al. (2012) Origin of non-cardiac endothelial cells from an Isl1+ lineage. FEBS Lett 586(13):1790-4 |
| abstractText | The cardiovascular system consists of many cell types with distinct embryonic origins. Cells from an Islet1 (Isl1)-expressing progenitor population make a substantial contribution to the developing heart. We reasoned that cells derived from Isl1-expressing progenitors might contribute more widely to the cardiovascular system. We show that cells derived from an Isl1-expressing progenitor lineage make a wide contribution to the systemic vasculature and that embryos conditionally deficient for Rac1 within this cell population develop defects in the non-cardiac vasculature. These data define new roles for Isl1 in the developing embryo and demonstrate a contribution of Isl1-expressing progenitors to vascular endothelium in vivo. |
