|  Help  |  About  |  Contact Us

Publication : Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity.

First Author  Melzer S Year  2017
Journal  Cell Rep Volume  19
Issue  5 Pages  1045-1055
PubMed ID  28467898 Mgi Jnum  J:251988
Mgi Id  MGI:6100015 Doi  10.1016/j.celrep.2017.04.024
Citation  Melzer S, et al. (2017) Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity. Cell Rep 19(5):1045-1055
abstractText  The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we identify long-range projecting GABAergic neurons in the primary (M1) and secondary (M2) motor cortex that target the dorsal striatum. This population of projecting GABAergic neurons comprises both somatostatin-positive (SOM(+)) and parvalbumin-positive (PV(+)) neurons that target direct and indirect pathway striatal output neurons as well as cholinergic interneurons differentially. Notably, optogenetic stimulation of M1 PV(+) and M2 SOM(+) projecting neurons reduced locomotion, whereas stimulation of M1 SOM(+) projecting neurons enhanced locomotion. Thus, corticostriatal GABAergic projections modulate striatal output and motor activity.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

14 Bio Entities

Trail: Publication

0 Expression