| First Author | Adams TE | Year | 1987 |
| Journal | Nature | Volume | 325 |
| Issue | 6101 | Pages | 223-8 |
| PubMed ID | 3543686 | Mgi Jnum | J:81385 |
| Mgi Id | MGI:2449236 | Doi | 10.1038/325223a0 |
| Citation | Adams TE, et al. (1987) Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature 325(6101):223-8 |
| abstractText | Transgenic mice expressing simian virus 40 T antigen under control of the insulin gene regulatory region vary in their response to this protein. Each lineage is characteristically either tolerant to T antigen, or not, in which case autoantibodies arise with high frequency, and lymphocytes infiltrate and disrupt the pancreatic islets. Both non-tolerance and the autoimmune response appear to result from delayed onset of T antigen expression during beta cell development. |
