| First Author | Chen Q | Year | 2009 |
| Journal | J Leukoc Biol | Volume | 85 |
| Issue | 3 | Pages | 539-43 |
| PubMed ID | 19074553 | Mgi Jnum | J:146059 |
| Mgi Id | MGI:3836648 | Doi | 10.1189/jlb.0308219 |
| Citation | Chen Q, et al. (2009) Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases. J Leukoc Biol 85(3):539-43 |
| abstractText | TLRs play a fundamental role in innate immune responses. Although Rho GTPases have been implicated in TLR-mediated signaling pathways, the molecules that control their activation in response to TLR engagement are largely unknown. IFN regulatory factor-4-binding protein (IBP; which is encoded by the gene Def6) is a unique type of activator for Rac that plays a crucial role in TCR-mediated signaling and adaptive immune responses. Here, we demonstrate that IBP/Def6 also controls innate immune responses by modulating TLR-induced signaling events. Mice deficient in IBP/Def6 are protected from LPS-induced septic shock. This protection is associated with a decrease in the production of proinflammatory cytokines and is accompanied by diminished activation of MAPKs and NF-kappaB. Our results thus identify IBP/Def6 as a novel component of the TLR4-induced signaling cascade that controls the production of proinflammatory cytokines. |
