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Allele : Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Mschu> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Markus Schubert
Primary Identifier  MGI:6861842 Allele Type  Targeted
Attribute String  Conditional ready, Constitutively active, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  The CAG-a loxP site flanked neo-Westphal stop-FLAG-mouse Foxo1* cassette followed by an FRT site-framed IRESeGFP expression cassette were inserted into ROSA26 locus via homologous recombination in the ES cells. The Foxo1 cDNA has mutations of T24 and S316 to A and S253 to D which confers the constitutively nuclear localized Foxo1 transcripts. In presence of cre recombinase, a loxP site flanked neo-Westphal stop sequence is removed to allow expression of mutated Foxo1 gene driven by CAG promoter.
  • mutations:
  • Insertion
  • synonyms:
  • FoxO1ADA,
  • FoxO1ADA
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1 Feature

Trail: Allele

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0 Mutation Involves

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