| First Author | Morris MD | Year | 1977 |
| Journal | Fed Proc | Volume | 36 |
| Pages | 1158 (Abstr.) | Mgi Jnum | J:83826 |
| Mgi Id | MGI:2663701 | Citation | Morris MD, et al. (1977) Tissue cholesterol storage disorder in BALB/c mice. Fed Proc 36:1158 (Abstr.) |
| abstractText | Full text of Abstract: 4691. Tissue Cholesterol Storage Disorder in BALB/c Mice. M.D. Morris, C. Bhuvaneswaran* and A.D. Boothe*, University of Arkansas for Medical Sciences, Little Rock, AR. 72201 A strain of BALB/c mice producing progeny of which 23% develop incoordination of locomotion and loss of weight leading to death at 70 days of age has been found. Every animal with clinical symptoms has an associated cholesterol storage in many tissues. Total serum cholesterol as well as its distribution as the free and esterified cholesterol were not greatly altered in affected mice (AM) when compared with their normal appearing litter mates (NM). The total cholesterol content of liver and spleen of AM was increased about 5 fold at the time of detection of clinical symptoms. In AM which were in the later stages of the disease, liver, lymph nodes, and spleen cholesterol were elevated 10-15 fold. Thymus cholesterol in these same animals was increased 25-30 fold. Other visceral organs also had an increased content of cholesterol but not to the same extent. In the liver, greater than 99% of the cholesterol of AM was present as unesterified cholesterol. Subcellular fractionation of liver from AM revealed a whitish particulate fraction (not observed with livers from NM) that sedimented loosely over the microsomal fraction. This fraction contained nearly 10% of total liver cholesterol. These results, together with the observation that the disorder was distributed equally between the sexes, suggest that the AM have a genetic defect in cholesterol transport and metabolism. |
