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Publication : Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.

First Author  Meng Y Year  2002
Journal  Neuron Volume  35
Issue  1 Pages  121-33
PubMed ID  12123613 Mgi Jnum  J:86283
Mgi Id  MGI:2679191 Doi  10.1016/s0896-6273(02)00758-4
Citation  Meng Y, et al. (2002) Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 35(1):121-33
abstractText  In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with Williams syndrome, a mental disorder with profound deficits in visuospatial cognition. However, the in vivo function of this family of kinases remains elusive. Using LIMK-1 knockout mice, we demonstrate a significant role for LIMK-1 in vivo in regulating cofilin and the actin cytoskeleton. Furthermore, we show that the knockout mice exhibited significant abnormalities in spine morphology and in synaptic function, including enhanced hippocampal long-term potentiation. The knockout mice also showed altered fear responses and spatial learning. These results indicate that LIMK-1 plays a critical role in dendritic spine morphogenesis and brain function.
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