| First Author | Meng Y | Year | 2002 |
| Journal | Neuron | Volume | 35 |
| Issue | 1 | Pages | 121-33 |
| PubMed ID | 12123613 | Mgi Jnum | J:86283 |
| Mgi Id | MGI:2679191 | Doi | 10.1016/s0896-6273(02)00758-4 |
| Citation | Meng Y, et al. (2002) Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 35(1):121-33 |
| abstractText | In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with Williams syndrome, a mental disorder with profound deficits in visuospatial cognition. However, the in vivo function of this family of kinases remains elusive. Using LIMK-1 knockout mice, we demonstrate a significant role for LIMK-1 in vivo in regulating cofilin and the actin cytoskeleton. Furthermore, we show that the knockout mice exhibited significant abnormalities in spine morphology and in synaptic function, including enhanced hippocampal long-term potentiation. The knockout mice also showed altered fear responses and spatial learning. These results indicate that LIMK-1 plays a critical role in dendritic spine morphogenesis and brain function. |
