| First Author | Fawal MA | Year | 2018 |
| Journal | Cell Rep | Volume | 23 |
| Issue | 10 | Pages | 2864-2873.e7 |
| PubMed ID | 29874574 | Mgi Jnum | J:272744 |
| Mgi Id | MGI:6280163 | Doi | 10.1016/j.celrep.2018.05.005 |
| Citation | Fawal MA, et al. (2018) Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation. Cell Rep 23(10):2864-2873.e7 |
| abstractText | Metabolic pathways, once seen as a mere consequence of cell states, have emerged as active players in dictating different cellular events such as proliferation, self-renewal, and differentiation. Several studies have reported a role for folate-dependent one-carbon (1C) metabolism in stem cells; however, its exact mode of action and how it interacts with other cues are largely unknown. Here, we report a link between the Eph:ephrin cell-cell communication pathway and 1C metabolism in controlling neural stem cell differentiation. Transcriptional and functional analyses following ephrin stimulation revealed alterations in folate metabolism-related genes and enzymatic activity. In vitro and in vivo data indicate that Eph-B forward signaling alters the methylation state of H3K4 by regulating 1C metabolism and locks neural stem cell in a differentiation-ready state. Our study highlights a functional link between cell-cell communication, metabolism, and epigenomic remodeling in the control of stem cell self-renewal. |
