| First Author | Laskowski A | Year | 2007 |
| Journal | Neuroreport | Volume | 18 |
| Issue | 10 | Pages | 1005-8 |
| PubMed ID | 17558285 | Mgi Jnum | J:123746 |
| Mgi Id | MGI:3719494 | Doi | 10.1097/WNR.0b013e32815277ab |
| Citation | Laskowski A, et al. (2007) NPY mediates basal and seizure-induced proliferation in the subcallosal zone. Neuroreport 18(10):1005-8 |
| abstractText | Stem cell niches exist around the lateral ventricle and in the subgranular layer of the dentate gyrus, supporting adult neurogenesis. Recently, a third germinal layer, the subcallosal zone has been identified supporting the generation of oligodendrocytes in the adult brain. We have previously described a proliferative role for neuropeptide Y on precursors in the dentate gyrus, caudal subventricular zone and subcallosal zone under basal conditions and in the dentate gyrus after seizures. Here we sought to determine a role for neuropeptide Y in seizure-induced proliferation in the subcallosal niche. Using the chemoconvulsant kainate and neuropeptide Y(-/-) mice with controls, we show an effect of neuropeptide Y on basal proliferation and demonstrate a significant reduction in seizure-induced proliferation in the subcallosal zone. |
