| First Author | Horváth BV | Year | 2002 |
| Journal | Immunol Lett | Volume | 80 |
| Issue | 3 | Pages | 151-4 |
| PubMed ID | 11803046 | Mgi Jnum | J:113511 |
| Mgi Id | MGI:3686907 | Doi | 10.1016/s0165-2478(01)00329-7 |
| Citation | Horvath BV, et al. (2002) Inverse regulation of interleukin-6 (IL-6) and IL-6 receptor in histamine deficient histidine decarboxylase-knock-out mice. Immunol Lett 80(3):151-4 |
| abstractText | Interleukin-6, a multifunctional cytokine upon binding to its receptor on hepatocytes regulates production of acute phase proteins involved in local and systemic inflammation. Gene expression and biosynthesis of IL-6 and its receptor (IL-6 R/gp130) is under complex regulation. Histamine, in addition to its principal role in immediate type hypersensitivity has been described to modulate IL-6 production and expression of IL-6 receptor. In this study, the IL-6 and IL-6 receptor expression was examined in histamine deficient histidine decarboxylase (HDC) knock-out mouse model. Our data suggest that in histamine deficient mice the inducibility of IL-6 is significantly reduced, whilst more IL-6 receptor/gp130 mRNA expresses in the liver than in wild type (HDC(+/+)) mice. These in vivo findings confirm earlier in vitro results and emphasize the efficacy of antihistamines in local IL-6 related processes. |
