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Publication : An autoradiographic study in mu-opioid receptor knockout mice.

First Author  Chen H Year  2000
Journal  Brain Res Mol Brain Res Volume  76
Issue  1 Pages  170-2
PubMed ID  10719227 Mgi Jnum  J:61005
Mgi Id  MGI:1354222 Doi  10.1016/s0169-328x(99)00346-0
Citation  Chen H, et al. (2000) An autoradiographic study in mu-opioid receptor knockout mice. Brain Res Mol Brain Res 76(1):170-2
abstractText  An autoradiographic study was carried out to study the opioid binding sites in a mu-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. Mu-opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional mu-opioid receptor does not affect the expression of the other two opioid receptors.
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