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Allele : Kras<tm4Tyj> Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
Primary Identifier  MGI:2429948 Allele Type  Targeted
Attribute String  Conditional ready, Null/knockout Gene  Kras
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  Glycine codon 12 was changed to aspartic acid (p.G12D) to encode an oncogenic form of the KRAS2 protein. A loxP site flanked STOP cassette was included upstream of the inserted Kras2 sequence, such that the mutant transcript would be expressed only after Cre-mediated recombination.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • LSL-KrasG12D,
  • Lox-Stop-Lox-Kras<G12D>,
  • K-Ras<L>,
  • Kras<G12D>,
  • Kras2<tm4Tyj>,
  • Kras2<tm4Tyj>,
  • Kras2tm14Tyj,
  • caKRas,
  • Kras<LSL-G12D>,
  • Kras<G12D>,
  • Kras<LSL-G12D>,
  • Lox-Stop-Lox-Kras<G12D>,
  • LSL-Kras G12D,
  • Kras<Lox>,
  • K-RasG12D,
  • LSL-K-ras<G12D>,
  • KR,
  • LSL-Kras<G12D>,
  • Kras<LSL-G12D>,
  • caKRas,
  • LSL-K-ras G12D,
  • LSL-KrasG12D,
  • Kras<Lox>,
  • Kras2tm14Tyj,
  • K-ras<LSL>,
  • LSL-Kras G12D,
  • K-RasG12D,
  • LSL-Kras<G12D>,
  • K-Ras<L>,
  • K-ras<LSL>,
  • K-Ras(G12D)<fl>,
  • KR,
  • LSL-K-ras G12D,
  • K-Ras(G12D)<fl>,
  • LSL-K-ras<G12D>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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Trail: Allele

0 Driven By

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Trail: Allele




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