| Primary Identifier | MGI:3848818 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(HLA-A24/H2-D/B2M)3Dvs |
| Inheritance Mode | Dominant | Strain of Origin | NOD/ShiLtDvs |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | This transgene encodes human B2-microglubulin (B2M) covalently linked to the alpha1 and alpha2 peptide binding domains of the human HLA-A24 MHC class I gene, as well as the alpha3, cytoplasmic and transmembrane domains of the murine H2-Db class I variant. Human HLA-A2.1 and HLA-A24 have both been associated with T1D in humans. |
