Primary Identifier | MGI:1856088 | Allele Type | Spontaneous |
Gene | Mitf | Inheritance Mode | Semidominant |
Strain of Origin | (C57BL x DBA)F1 | Is Recombinase | false |
Is Wild Type | false |
description | Combination heterozygotes of MitfMi-wh/MitfMi, MitfMi-wh/MitfMi-b, and MitfMi-wh/MitfMi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967, J:19656). MitfMi-b/MitfMi-wh agouti mice are light cream with white spots and ruby eyes (J:15061). |
molecularNote | T-to-A transversion at bp 764, which leads to an isoleucine to asparagine substitution at amino acid 212 in the encoded protein (p.I212N). This mutation is in the basic region of the protein. |