| First Author | Panten J | Year | 2023 |
| Journal | bioRxiv | Mgi Jnum | J:343787 |
| Mgi Id | MGI:7571175 | Doi | 10.1101/2023.12.04.569933 |
| Citation | Panten J, et al. (2023) Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage. bioRxiv |
| abstractText | The Four Core Genotypes (FCG) is a mouse model system heavily used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of multiple genes including the auto-immune master regulator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on FCG mice. |
