| First Author | Hong R | Year | 2020 |
| Journal | Int Immunol | Volume | 32 |
| Issue | 1 | Pages | 17-26 |
| PubMed ID | 31412363 | Mgi Jnum | J:282961 |
| Mgi Id | MGI:6384411 | Doi | 10.1093/intimm/dxz055 |
| Citation | Hong R, et al. (2020) Distinct roles of BCNP1 in B-cell development and activation. Int Immunol 32(1):17-26 |
| abstractText | B-cell novel protein 1 (BCNP1) has recently been identified as a new B-cell receptor (BCR) signaling molecule but its physiological function remains unknown. Here, we demonstrate that mice deficient in BCNP1 exhibit impaired B-cell maturation and a reduction of B-1a cells. BCNP1-deficient spleen B cells show enhanced survival, proliferation and Ca2+ influx in response to BCR cross-linking as compared with wild-type spleen B cells. Consistently, mutant B cells show elevated phosphorylation of SYK, B-cell linker protein (BLNK) and PLCgamma2 upon BCR cross-linking. In vivo, BCNP1-deficient mice exhibit enhanced humoral immune responses to T-independent and T-dependent antigens. Moreover, aged mutant mice contain elevated levels of serum IgM and IgG3 antibodies and exhibit polyclonal and monoclonal B-cell expansion in lymphoid organs. These results reveal distinct roles for BCNP1 in B-cell development, activation and homeostasis. |
