| First Author | Kawahara M | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 27 | Pages | 5178-84 |
| PubMed ID | 17959172 | Mgi Jnum | J:127743 |
| Mgi Id | MGI:3764766 | Doi | 10.1016/j.febslet.2007.10.004 |
| Citation | Kawahara M, et al. (2007) Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term. FEBS Lett 581(27):5178-84 |
| abstractText | Recently, we reported that the restored regulation of imprinted gene expression from two regions -H19 differentially methylated region (H19-DMR) and intergenic germline-derived DMR (IG-DMR) - is sufficient for accomplishing full-term development in mice. In the present study, we determined the developmental ability of the bi-maternal embryos (BMEs) containing the non-growing oocyte genome with the IG-DMR deletion (ng(Deltach12)) and fully-grown (fg) oocyte genome. Foetuses derived from ng(Deltach12)/fg BMEs were alive at E19.5 but could not survive further. Comparison with BMEs derived from Igf2+/- ng/fg genomes suggests that bi-allelic H19 expression might be involved in foetal development. |
