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Allele : Tnfsf11<em1Caob> tumor necrosis factor (ligand) superfamily, member 11; endonuclease-mediated mutation 1, Charles O'Brien

Primary Identifier  MGI:6358014 Allele Type  Endonuclease-mediated
Gene  Tnfsf11 Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  CRISPR/Cas9 genome editing technology was used to create a deletion of sequences encoding the stalk domain, which contains all known proteolytic cleavage sites. The protein encoded by the modified allele lacks amino acids Ile133 to Ser149 and contains Arg at the former Trp150 position.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • sRANKL,
  • sRANKL
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories