| First Author | Pfeiffenberger C | Year | 2005 |
| Journal | Nat Neurosci | Volume | 8 |
| Issue | 8 | Pages | 1022-7 |
| PubMed ID | 16025107 | Mgi Jnum | J:101436 |
| Mgi Id | MGI:3604034 | Doi | 10.1038/nn1508 |
| Citation | Pfeiffenberger C, et al. (2005) Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping. Nat Neurosci 8(8):1022-7 |
| abstractText | In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated neural activity in ephrin mutants led to overlapping retinal projections that were located in inappropriate regions of the dLGN. Thus, ephrin-As and neural activity act together to control patterning of eye-specific retinogeniculate layers. |
