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Allele : Aldh1a1<tm1Gdu> aldehyde dehydrogenase family 1, subfamily A1; targeted mutation 1, Gregg Duester

Primary Identifier  MGI:2667220 Allele Type  Targeted
Attribute String  Null/knockout Gene  Aldh1a1
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 11 was replaced by a PGK-neomycin gene. This results in eliminating the region containing the substrate binding pocket and the tetramerization domain in any mRNA that might be transcribed. Resulting mice were genotyped by Southern blots. Absence of protein product was established by Western blot analysis.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Raldh1<->,
  • Raldh1<->
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

36 Publication categories

Trail: Allele