| First Author | Yoder J | Year | 2001 |
| Journal | Science | Volume | 291 |
| Issue | 5510 | Pages | 1987-91 |
| PubMed ID | 11239162 | Mgi Jnum | J:76696 |
| Mgi Id | MGI:2179982 | Doi | 10.1126/science.1057176 |
| Citation | Yoder J, et al. (2001) Requirement for the SLP-76 adaptor GADS in T cell development. Science 291(5510):1987-91 |
| abstractText | GADS is an adaptor protein implicated in CD3 signaling because of its ability to link SLP-76 to LAT. A GADS-deficient mouse was generated by gene targeting, and the function of GADS in T cell development and activation was examined. GADS- CD4-CD8- thymocytes exhibited a severe block in proliferation but still differentiated into mature T cells. GADS- thymocytes failed to respond to CD3 cross-linking in vivo and were impaired in positive and negative selection. Immunoprecipitation experiments revealed that the association between SLP-76 and LAT was uncoupled in GADS- thymocytes. These observations indicate that GADS is a critical adaptor for CD3 signaling. |
