| Primary Identifier | MGI:4415610 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Itm2b |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A decamer duplication in the 3' region of the gene (right before the stop codon within exon 6, that leads to the production of a longer, 277 aa protein) was inserted. In addition, a humanizing substitution A-G (acc-gcc = Threonine-Alanine) at the 12th codon of exon 6 was introduced. Western blot analysis detected marked expression of the mutant precursor protein. |
