| First Author | Franco S | Year | 2002 |
| Journal | Cancer Res | Volume | 62 |
| Issue | 2 | Pages | 552-9 |
| PubMed ID | 11809709 | Mgi Jnum | J:74001 |
| Mgi Id | MGI:2157286 | Citation | Franco S, et al. (2002) Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res 62(2):552-9 |
| abstractText | Endothelial cell function and angiogenesis are modulated by aging. However, the underlying molecular mechanisms are largely unknown. Here we show that in telomerase-deficient mice Terc(-/-), short telomeres result in a sharp decrease in angiogenesis in both Matrigel implants and murine melanoma grafts. In the latter model, decreased microvessel counts in late generation Terc(-/-) mice led to diminished tumor cell proliferation and increased tumor cell apoptosis, resulting in a lower tumor growth rate. Our results indicate that telomere length is a key molecular determinant of angiogenic potential in vivo and that telomere length modifiers and telomerase inhibitors could be useful antiangiogenic agents. |
