| First Author | Gravaghi C | Year | 2008 |
| Journal | Int J Obes (Lond) | Volume | 32 |
| Issue | 11 | Pages | 1716-9 |
| PubMed ID | 18725892 | Mgi Jnum | J:142259 |
| Mgi Id | MGI:3820784 | Doi | 10.1038/ijo.2008.149 |
| Citation | Gravaghi C, et al. (2008) Obesity enhances gastrointestinal tumorigenesis in Apc-mutant mice. Int J Obes (Lond) 32(11):1716-9 |
| abstractText | Epidemiological evidence indicates a link between obesity and human colon cancer. A putative association between obesity and colon tumorigenesis has been explored experimentally using chemical carcinogens administered to obese rodents. The main objective of this study was to generate a new mouse line that displays both obesity and intestinal tumorigenesis. To this end, we have generated C57BLKS-mLepr(db/db); Apc(1638N/+) mice combining both db and Apc mutations. The db mutation results in obesity and type 2 diabetes, the Apc mutation is a key initiating event of intestinal neoplasia. All mice were euthanized at 6 months of age and all regions of the gastrointestinal tract examined for tumors. The results show that the combination of Apc(1638N/+) and db mutations not only enhanced mutant Apc-driven small intestinal tumorigenesis but also induced gastric and colonic tumors. Homozygous db mice did not develop gastrointestinal neoplasia. These findings indicate that obesity associated with type 2 diabetes promotes gastrointestinal tumorigenesis in Apc-deficient mice and provides evidence of a mechanistic link between obesity and colorectal neoplasia. |
