| Primary Identifier | MGI:3054784 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Aipl1 |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin resistance gene was inserted into intron 2. Analysis of retinal mRNA indicated that transcript levels were severely reduced. Immunofloresence indicated a lower abundance of protein in the inner segment of photoreceptors of mutants. Quantification on immunoblots demonstrated that this is allele is a strong hypomorph, with the level of protein in mutants decreased to 20-25% of that for wild-type animals. |
