| Primary Identifier | MGI:2182901 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Faah |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 1 and approximately 2kb of upstream sequence were replaced by a PGK-neo selection cassette. Western blot analysis of brain and liver protein extracts and immunofluorescence analysis of cerebral sections showed an absence of encoded protein in homozygous mutant mice. Assays using labeled substrate showed significant reductions (50-100 fold) of hydrolytic activity in homozygous mutant mice. |
